28 January 2015

Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes that Promote Autophagic Tau Clearance



Mackenzie D. Martin, Laurent Calcul, Courtney Smith, Umesh K. Jinwal, Sarah N. Fontaine, April Darling, Kent Seeley, Lukasz Wojtas, Malathi Narayan, Jason E. Gestwicki, Garry R. Smith, Allen B. Reitz, Bill J. Baker, and Chad A. Dickey

ACS Chemical Biology 2015. DOI:10.1021/cb501013w.

14 January 2015

Identification of Human Semiochemicals Attractive to the Major Vectors of Onchocerciasis


Figure 1

Ryan M. Young, Nathan D. Burkett-Cadena, Tommy W. McGaha Jr, Mario A. Rodriguez-Perez, Laurent D. ToƩ, Monsuru A. Adeleke, Moussa Sanfo, Traore Soungalo, Charles R. Katholi, Raymond Noblet, Henry Fadamiro, Jose L. Torres-Estrada, Mario C. Salinas-Carmona, Bill J. Baker, Thomas R. Unnasch, Eddie W. Cupp

PLOS Neglected Tropical Diseases 2015, 9(1): e3450. - DOI:10.1371/journal.pntd.0003450.

30 December 2014

HAPPY NEW YEAR!

Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery



Carrie Waterman, Laurent Calcul, Jeremy Beau, Wai Sheung Ma, Matthew D. Lebar, Jacqueline L. von Salm, Charles Harter, Tina Mutka, Lindsay C. Morton, Patrick Maignan, Betty Barisic, Alberto van Olphen, Dennis E. Kyle, Lilian Vrijmoed, Ka-Lai Pang, Cedric J. Pearce, and Bill J. Baker

Medicinal Research Reviews 2014, DOI: 10.1002/med.21335.

16 July 2014

A potent antimalarial trichothecene from hyphomycete species


Full-size image (25 K)

Carrie Waterman, Laurent Calcul, Tina Mutka, Dennis E. Kyle, Cedric J. Pearce, Bill J. Baker

Tetrahedron Letters 2014, 55(29) 3989-3991. DOI: 10.1016/j.tetlet.2014.05.056.

21 May 2014

Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery



Yuri Pevzner, Daniel N. Santiago, Jacqueline L. von Salm, Rainer S. Metcalf, Kenyon G. Daniel, Laurent Calcul, H. Lee Woodcock, Bill J. Baker, Wayne C. Guida, and Wesley H. Brooks

AIMS Molecular Science 2014, 1(2) 81-98. DOI: 10.3934/molsci.2014.2.81.